Inhaled but not intravenous milrinone prevents pulmonary endothelial dysfunction after cardiopulmonary bypass
نویسندگان
چکیده
منابع مشابه
Selective endothelial dysfunction in conscious dogs after cardiopulmonary bypass.
It has previously been demonstrated that cardiopulmonary bypass (CPB) causes prolonged pulmonary vascular hyperreactivity (D.P. Nyhan, J.M. Redmond, A.M. Gillinov, K. Nishiwaki, and P.A. Murray. J. Appl. Physiol. 77: 1584-1590, 1994). This study investigated the effects of CPB on endothelium-dependent (acetylcholine and bradykinin) and endothelium-independent (sodium nitroprusside) pulmonary va...
متن کاملCombined usage of inhaled and intravenous milrinone in pulmonary hypertension after heart valve surgery.
Secondary pulmonary hypertension is a frequent condition after heart valve surgery. It may significantly complicate the perioperative management and increase patients' morbidity and mortality. The treatment has not been yet completely defined principally because of lack of the selectivity of drugs for the pulmonary vasculature. The usage of inhaled milrinone could be the possible therapeutic op...
متن کاملMatrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery
BACKGROUND Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB. METHODS Thirty patients undergoing elective cardiac surgery were included. Arterial blood was sampled at 6 sequential points (bef...
متن کاملUse of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass.
BACKGROUND Increased pulmonary vascular resistance is common in congenital heart disease and is exacerbated by cardiopulmonary bypass (CPB). We investigated whether CPB is responsible for pulmonary endothelial dysfunction and contributes to postoperative pulmonary hypertension. METHODS AND RESULTS We infused the endothelium-dependent vasodilator acetylcholine (ACH) into the pulmonary circulat...
متن کاملUse of Inhaled Nitric Oxide and Acetlcholine in the Evaluation of Pulmonary Hypertension and Endothelial Function After Cardiopulmonary Bypass
Background. Increased pulmonary vascular resistance is common in congenital heart disease and is exacerbated by cardiopulmonary bypass (CPB). We investigated whether CPB is responsible for pulmonary endothelial dysfunction and contributes to postoperative pulmonary hypertension. Methods and Results. We infused the endothelium-dependent vasodilator acetylcholine (ACH) into the pulmonary circulat...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2005
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2004.09.011